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What should I tell my health care providers before I take Azilect?

You should not take rasagiline if you are allergic to it. Many medicines can interact with rasagiline and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

• cyclobenzaprine (a muscle relaxer);

• dextromethorphan (contained in many over-the-counter cough medicines);

• meperidine (Demerol);

• methadone;

• St. John's wort; or

• tramadol (Ultram, Ultracet).

Do not use rasagiline if you have used any other MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, tranylcypromine, and others. To make sure rasagiline is safe for you, tell your doctor if you have:

• high or low blood pressure;

• liver disease;

• if you take an antidepressant; or

• if you take ciprofloxacin (an antibiotic).

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether rasagiline will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Azilect. It is not known whether rasagiline passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

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